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Article

The association of transporter ABCC2 (MRP2) genetic variation and drug-induced hyperbilirubinemia.

Journal of the Chinese Medical Association : JCMA - 1 Feb 2021

Huang Yi-Shin, Chang Tien-En, Perng Chin-Lin, Huang Yi-Hsiang

Abstract excerpt

BACKGROUND: Hyperbilirubinemia is a predictor of severe drug-induced liver injury (DILI). Hepatobiliary ATP-binding cassette (ABC) transporters play an important role in the transportation of many drugs and bilirubin; however, little is known about these transporters and the risk of DILI. The aim of this study was to explore associations between genetic variations in important ABC transporters and susceptibility...

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Source

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Identifiers

PMID: 33323685
DOI: 10.1097/JCMA.0000000000000470
PMCID: PMC12966164

Genes

ABCC2
ABCB1
ABCB11
ABCB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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