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Article

Genetic variants may play an important role in mRNA-miRNA interaction: evidence for haplotype-dependent downregulation of ABCC2 (MRP2) by miRNA-379.

Pharmacogenetics and genomics - 1 Jun 2014

Werk Anneke N, Bruckmueller Henrike, Haenisch Sierk, Cascorbi Ingolf

Abstract excerpt

BACKGROUND: The functional influence of single-nucleotide polymorphisms (SNPs) of the ATP-binding cassette (ABC) transporter ABCC2 (MRP2) has been characterized in numerous studies. The aim of this study was to address the question of whether distinct ABCC2 haplotypes, which differ in their mRNA secondary structures, show an influence on the degree of mRNA and protein downregulation through miRNA interaction....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24743544
DOI: 10.1097/FPC.0000000000000046

Genes

ABCC2

Variants

Provenance

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