Article
A role for casein kinase 2 in the mechanism underlying circadian temperature compensation.
Cell - 15 May 2009
Mehra Arun, Shi Mi, Baker Christopher L, Colot Hildur V, Loros Jennifer J, Dunlap Jay C
Abstract excerpt
Temperature compensation of circadian clocks is an unsolved problem with relevance to the general phenomenon of biological compensation. We identify casein kinase 2 (CK2) as a key regulator of temperature compensation of the Neurospora clock by determining that two long-standing clock mutants, chrono and period-3, displaying distinctive alterations in compensation encode the beta1 and alpha subunits of CK2,...
Topics
- Casein Kinase II
- Circadian Rhythm
- Gene Dosage
- Mutation
- Neurospora crassa
- Phosphoric Monoester Hydrolases
- Phosphotransferases
- Protein Subunits
- Temperature