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Article

Inhibition of CREB function in mouse epidermis reduces papilloma formation.

Molecular cancer research : MCR - 1 May 2009

Rozenberg Julian, Rishi Vikas, Orosz Andras, Moitra Jaideep, Glick Adam, Vinson Charles

Abstract excerpt

We used a double transgenic tetracycline system to conditionally express A-CREB, a dominant negative protein that prevents the DNA binding and function of cAMP-responsive element binding protein (CREB) family members, in mouse basal epidermis using the keratin 5 promoter. There was no phenotype in the adult. However, following a 7,12-dimethylbenz(a)anthracene (DMBA)/phorbol-12-myristate-13-acetate two-stage skin...

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Source

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Identifiers

PMID: 19435810
DOI: 10.1158/1541-7786.MCR-08-0011
PMCID: PMC7291700

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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