Article
Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis.
Molecular carcinogenesis - 1 Jan 2007
Chan Edward L, Peace Belinda E, Toney Kenya, Kader Sarah A, Pathrose Peterson, Collins Margaret H, Waltz Susan E
Abstract excerpt
Mice with conditional gene deletions have been extremely valuable in allowing investigators to study the genes of interest in a tissue-specific manner. The Cre-loxP recombination system provides a powerful tool to produce targeted rearrangements of particular genes. The keratin 5-Cre recombinase (K5Cre) transgenic mouse line has been used to generate skin specific gene deletions. We found that the K5Cre mice...
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