Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.

Cancer research - 1 May 2009

Scholl Florence A, Dumesic Phillip A, Barragan Deborah I, Harada Kazutoshi, Charron Jean, Khavari Paul A

Abstract excerpt

The Ras/Raf/Mek/Erk mitogen-activated protein kinase pathway regulates fundamental processes in normal and malignant cells, including proliferation, differentiation, and cell survival. Mutations in this pathway have been associated with carcinogenesis and developmental disorders, making Mek1 and Mek2 prime therapeutic targets. In this study, we examined the requirement for Mek1 and Mek2 in skin neoplasia using...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to MAP Kinase Kinase 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase 2

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to Oncogene Protein v-akt

Share to Papilloma

Share to Tetradecanoylphorbol Acetate

Source

Open in PubMed Open full text

Identifiers

PMID: 19383924
DOI: 10.1158/0008-5472.CAN-08-1963
PMCID: PMC3576816

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Selective role for Mek1 but not Mek2 in the induction of epidermal neoplasia.PMID 19383924Read ↗

p38delta Mitogen-activated protein kinase is essential for skin tumor development in mice.Semantic proximity Read ↗

Fine-tuning of MEK signaling is pivotal for limiting B and T cell activation.Semantic proximity Read ↗

Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions.Semantic proximity Read ↗

Inhibition of Cellular MEK/ERK Signaling Suppresses Murine Papillomavirus Type 1 Replicative Activities and Promotes Tumor RegressionSemantic proximity Read ↗

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.Semantic proximity Read ↗

Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction.Semantic proximity Read ↗

Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis.Semantic proximity Read ↗

Frequent codon 12 Ki-ras mutations in mouse skin tumors initiated by N-methyl-N'-nitro-N-nitrosoguanidine and promoted by mezerein.Semantic proximity Read ↗

Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.Semantic proximity Read ↗

Mutually exclusive mutations of the Pten and ras pathways in skin tumor progression.Semantic proximity Read ↗

Cancer Mutations: Molecular MEKanisms.Semantic proximity Read ↗

Differential tumor biology effects of double-initiation in a mouse skin chemical carcinogenesis model comparing wild type versus protein kinase Cepsilon overexpression mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.