Article
FVB/N mice: an inbred strain sensitive to the chemical induction of squamous cell carcinomas in the skin.
Carcinogenesis - 1 Nov 1993
Hennings H, Glick A B, Lowry D T, Krsmanovic L S, Sly L M, Yuspa S H
Abstract excerpt
The widespread use of FVB/N mice for the establishment of transgenic lines containing active oncogenes suggested the importance of testing the parent FVB/N mice for sensitivity to experimental carcinogenesis. After initiation of mouse skin by a single treatment with 7,12-dimethylbenz[a]anthracene (DMBA) and promotion by 20 weekly applications of 12-O-tetradecanoylphorbol-13-acetate (TPA), the skin tumor incidence...
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