Article
The malignant capacity of skin tumours induced by expression of a mutant H-ras transgene depends on the cell type targeted.
Current biology : CB - 23 Apr 1998
Brown K, Strathdee D, Bryson S, Lambie W, Balmain A
Abstract excerpt
BACKGROUND: . Pinpointing the cells from which tumours arise is a major challenge n tumour biology. Previous work has shown that the targeted expression of a mutant ras gene within the interfollicular cell compartment of mouse skin induces the formation of benign papillomas, but these do not spontaneously progress to malignancy. We have investigated the carcinogenic effects of expressing the same oncogene in a...
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