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Article

CCAAT/enhancer binding protein-beta is a mediator of keratinocyte survival and skin tumorigenesis involving oncogenic Ras signaling.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002

Zhu Songyun, Yoon Kyungsil, Sterneck Esta, Johnson Peter F, Smart Robert C

Abstract excerpt

The basic leucine zipper transcription factor CCAAT/enhancer binding protein-beta (C/EBPbeta) is expressed in many cell types, including keratinocytes. C/EBPbeta activity can be increased by phosphorylation through pathways stimulated by oncogenic Ras, although the biological implications of Ras-C/EBPbeta signaling are not currently understood. We report here that C/EBPbeta-nullizygous mice are completely...

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Identifiers

PMID: 11756662
DOI: 10.1073/pnas.012437299
PMCID: PMC117540

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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