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Article

Conditional epidermal expression of TGFβ1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia

31 Jul 2001

Abstract excerpt

To study the role of transforming growth factor type beta1 (TGFbeta1) in epidermal growth control and disease, we have generated a conditional expression system by using the bovine keratin 5 promoter to drive expression of the tetracycline-regulated transactivators tTA and rTA, and a constitutively active mutant of TGFbeta1 linked to the tetO target sequence for the transactivator. This model allows for induction...

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PMID: 11481479
DOI: 10.1073/pnas.161016098

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Source receipt: pubmed, retrieved 7 Sept 2026.

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