Article
Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.
Molecular and cellular biology - 1 Oct 1992
Vassar R, Hutton M E, Fuchs E
Abstract excerpt
The induction of skin papillomas in mice can be divided into two different stages. Chemical initiation frequently elicits mutations in the Ha-ras gene, leading to the constitutive activation of ras. The second step, promotion, involves repetitive topical application of phorbol esters or wounding, leading to epidermal hyperproliferation and papilloma formation. We have found that overexpression of transforming...
Topics
- Animals
- Base Sequence
- DNA, Neoplasm
- Disease Models, Animal
- Gene Amplification
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Mice
- Mice, Transgenic
- Molecular Sequence Data
- Mutation