Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.

Cancer research - 1 Feb 2001

Zhou H M, Bolon I, Nichols A, Wohlwend A, Vassalli J D

Abstract excerpt

The serpin plasminogen activator inhibitor (PAI) type 2 is expressed in differentiated epidermal keratinocytes. To explore its role in this tissue, we studied the impact of PAI-2 overexpression on epidermal differentiation and skin carcinogenesis. A mouse PAI-2-encoding transgene was targeted to basal epidermis and hair follicles under the control of the bovine keratin type 5 gene promoter. Two mouse lines were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 9,10-Dimethyl-1,2-benzanthracene
Share to Carcinogens

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Epidermal Cells

Share to Epidermis

Share to Keratinocytes

Share to Mice, Inbred CBA

Share to Papilloma

Share to Urokinase-Type Plasminogen Activator

Source

Identifiers

PMID: 11221892

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.PMID 11221892Read ↗

Transgenic cyclooxygenase-2 overexpression sensitizes mouse skin for carcinogenesis.Semantic proximity Read ↗

Abnormal differentiation of epidermis in transgenic mice constitutively expressing cyclooxygenase-2 in skin.Semantic proximity Read ↗

Transgenic overexpression of transforming growth factor alpha bypasses the need for c-Ha-ras mutations in mouse skin tumorigenesis.Semantic proximity Read ↗

Transgenic mice provide new insights into the role of TGF-alpha during epidermal development and differentiation.Semantic proximity Read ↗

Cyclooxygenase-2 overexpression in the skin of transgenic mice results in suppression of tumor development.Semantic proximity Read ↗

Decreases in phorbol ester-induced papilloma development in v-Ha-ras transgenic TG.AC mice during reduced gene dosage of bcl-2.Semantic proximity Read ↗

Collagenase Expression in Transgenic Mouse Skin Causes Hyperkeratosis and Acanthosis and Increases Susceptibility to TumorigenesisSemantic proximity Read ↗

Enhanced human papillomavirus type 8 oncogene expression levels are crucial for skin tumorigenesis in transgenic miceSemantic proximity Read ↗

Targeted expression of activated erbB-2 to the epidermis of transgenic mice elicits striking developmental abnormalities in the epidermis and hair follicles.Semantic proximity Read ↗

Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.Semantic proximity Read ↗

Impaired skin regeneration and remodeling after cutaneous injury and chemically induced hyperplasia in taps-transgenic mice.Semantic proximity Read ↗

Homozygous K5Cre transgenic mice have wavy hair and accelerated malignant progression in a murine model of skin carcinogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.