Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.

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Article

Overexpression of plasminogen activator inhibitor type 2 in basal keratinocytes enhances papilloma formation in transgenic mice.

Cancer research - 1 Feb 2001

Zhou H M, Bolon I, Nichols A, Wohlwend A, Vassalli J D

Abstract excerpt

The serpin plasminogen activator inhibitor (PAI) type 2 is expressed in differentiated epidermal keratinocytes. To explore its role in this tissue, we studied the impact of PAI-2 overexpression on epidermal differentiation and skin carcinogenesis. A mouse PAI-2-encoding transgene was targeted to basal epidermis and hair follicles under the control of the bovine keratin type 5 gene promoter. Two mouse lines were...

Topics

9,10-Dimethyl-1,2-benzanthracene
Animals
Carcinogens
Cell Differentiation
Crosses, Genetic
Epidermal Cells
Epidermis
Female
Gene Expression
Genetic Predisposition to Disease
Keratinocytes
Male
Mice
Mice, Inbred CBA
Mice, Transgenic

Source

Open in PubMed

Identifiers

PMID: 11221892

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Papilloma

Plasminogen Activator Inhibitor 2

Polymerase Chain Reaction