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Article

Immunoglobulin switch mu sequence causes RNA polymerase II accumulation and reduces dA hypermutation.

The Journal of experimental medicine - 8 Jun 2009

Rajagopal Deepa, Maul Robert W, Ghosh Amalendu, Chakraborty Tirtha, Khamlichi Ahmed Amine, Sen Ranjan, Gearhart Patricia J

Abstract excerpt

Repetitive DNA sequences in the immunoglobulin switch mu region form RNA-containing secondary structures and undergo hypermutation by activation-induced deaminase (AID). To examine how DNA structure affects transcription and hypermutation, we mapped the position of RNA polymerase II molecules and mutations across a 5-kb region spanning the intronic enhancer to the constant mu gene. For RNA polymerase II, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19433618
DOI: 10.1084/jem.20082514
PMCID: PMC2715057

Genes

UNG

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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