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Article

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.

The Journal of experimental medicine - 4 Sept 2006

Xue Kanmin, Rada Cristina, Neuberger Michael S

Abstract excerpt

Immunoglobulin (Ig) class switching is initiated by deamination of C-->U within the immunoglobulin heavy chain locus, catalyzed by activation-induced deaminase (AID). In the absence of uracil-DNA glycosylase (UNG) and the homologue of bacterial MutS (MSH)-2 mismatch recognition protein, the resul...

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Share to AICDA (Activation-Induced Cytidine Deaminase)
Share to Cytidine Deaminase
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Immunoglobulin Switch Region

Share to Mice, Inbred CBA

Share to MutS Homolog 2 Protein

Share to Somatic Hypermutation, Immunoglobulin

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Source

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Identifiers

PMID: 16894013
DOI: 10.1084/jem.20061067
PMCID: PMC2118391

Genes

UNG
MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16894013-2026-09-02.1. Manifest publication-graph-cohort-2026-09-02.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

The in vivo pattern of AID targeting to immunoglobulin switch regions deduced from mutation spectra in msh2-/- ung-/- mice.PMID 16894013Read ↗

Somatic Hypermutation and Class Switch Recombination in Msh6−/−Ung−/− Double-Knockout MiceSemantic proximity Read ↗

Uracil excision by endogenous SMUG1 glycosylase promotes efficient Ig class switching and impacts on A:T substitutions during somatic mutation.Semantic proximity Read ↗

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.Semantic proximity Read ↗

Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C bias.Semantic proximity Read ↗

AID-initiated DNA lesions are differentially processed in distinct B cell populations.Semantic proximity Read ↗

AID Binds Cooperatively with UNG and Msh2-Msh6 to Ig Switch Regions Dependent upon the AID C TerminusSemantic proximity Read ↗

Interplay between Target Sequences and Repair Pathways Determines Distinct Outcomes of AID-Initiated Lesions.Semantic proximity Read ↗

UNG shapes the specificity of AID-induced somatic hypermutation.Semantic proximity Read ↗

A Hyper-IgM Syndrome Mutation in Activation-Induced Cytidine Deaminase Disrupts G-Quadruplex Binding and Genome-wide Chromatin Localization.Semantic proximity Read ↗

Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.Semantic proximity Read ↗

The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.Semantic proximity Read ↗

Mismatch recognition and uracil excision provide complementary paths to both Ig switching and the A/T-focused phase of somatic mutation.Semantic proximity Read ↗

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