Article

Immunoglobulin enhancers increase RNA polymerase 2 stalling at somatic hypermutation target sequences

2021-09-17

Abstract excerpt

<h4>ABSTRACT</h4> Somatic hypermutation (SHM) drives the genetic diversity of immunoglobulin (Ig) genes in activated B cells and supports the generation of antibodies with increased affinity for antigen. SHM is targeted to Ig genes by their enhancers (DIVACs; diversification activators), but how the enhancers mediate this activity is unknown. We show using chicken DT40 B cells that highly active DIVACs increase t...

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Literature Corpus work: 2af694f3-10ce-5961-8d38-e3f521140ceb
DOI: 10.1101/2021.09.16.460442

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