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Article

Controlling somatic hypermutation in immunoglobulin variable and switch regions.

Immunologic research - 1 Jul 2010

Maul Robert W, Gearhart Patricia J

Abstract excerpt

Activation-induced deaminase (AID) is a B-cell-specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in the immunoglobulin loci. There is an intricate interplay between faithful DNA repair and mutagenic DNA repair during...

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Identifiers

PMID: 20082153
DOI: 10.1007/s12026-009-8142-5
PMCID: PMC2952935

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Source receipt: pubmed, retrieved 7 Sept 2026.

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