Controlling somatic hypermutation in immunoglobulin variable and switch regions.

doi:10.1007/s12026-009-8142-5

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Article

Controlling somatic hypermutation in immunoglobulin variable and switch regions.

Immunologic research - 1 Jul 2010

Maul Robert W, Gearhart Patricia J

Abstract excerpt

Activation-induced deaminase (AID) is a B-cell-specific enzyme required for initiating the mechanisms of affinity maturation and isotype switching of antibodies. AID functions by deaminating cytosine to uracil in DNA, which initiates a cascade of events resulting in mutations and strand breaks in the immunoglobulin loci. There is an intricate interplay between faithful DNA repair and mutagenic DNA repair during...

Topics

Animals
Base Sequence
Cytidine Deaminase
DNA Repair
Humans
Immunoglobulin Class Switching
Immunoglobulin Switch Region
Immunoglobulin Variable Region
Immunoglobulins
Mice
Mutation
Somatic Hypermutation, Immunoglobulin
Uracil-DNA Glycosidase
AICDA (Activation-Induced Cytidine Deaminase)

Source

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Identifiers

PMID: 20082153
DOI: 10.1007/s12026-009-8142-5
PMCID: PMC2952935

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