Article
Altered spectra of hypermutation in DNA repair-deficient mice.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001
Winter D B, Gearhart P J
Abstract excerpt
Affinity maturation of the humoral immune response is based on the ability of immunoglobulin variable genes to undergo a process of rapid and extensive somatic mutation followed by antigenic selection for antibodies with higher affinity. While the behaviour of this somatic hypermutation phenomeno...
Topics
- Animals
- Ataxia Telangiectasia Mutated Proteins
- Base Pair Mismatch
- Cell Cycle Proteins
- DNA Repair
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase
- Mice
- Mice, Mutant Strains
- Mutation
- Protein Serine-Threonine Kinases