Article
Altered spectra of hypermutation in DNA repair-deficient mice.
Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 29 Jan 2001
Winter D B, Gearhart P J
Abstract excerpt
Affinity maturation of the humoral immune response is based on the ability of immunoglobulin variable genes to undergo a process of rapid and extensive somatic mutation followed by antigenic selection for antibodies with higher affinity. While the behaviour of this somatic hypermutation phenomenon has been well characterized over the last 20 years, the molecular mechanism responsible for inserting mutations has...
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