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Article

Emerging links between hypermutation of antibody genes and DNA polymerases.

Nature reviews. Immunology - 1 Dec 2001

Gearhart P J, Wood R D

Abstract excerpt

Substantial antibody variability is created when nucleotide substitutions are introduced into immunoglobulin variable genes by a controlled process of hypermutation. Evidence points to a mechanism involving DNA repair events at sites of targeted breaks. In vertebrate cells, there are many recently identified DNA polymerases that inaccurately copy templates. Some of these are candidates for enzymes that introduce...

Read the complete abstract on PubMed

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11905827
DOI: 10.1038/35105009

Genes

POLH
POLI
POLM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Emerging links between hypermutation of antibody genes and DNA polymerases.PMID 11905827Read ↗

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