Article
IL1B polymorphisms modulate cystic fibrosis lung disease.
Pediatric pulmonology - 1 Jun 2009
Levy Hara, Murphy Amy, Zou Fei, Gerard Craig, Klanderman Barbara, Schuemann Brooke, Lazarus Ross, García K Christopher, Celedón Juan C, Drumm Mitch, Dahmer Mary, Quasney Michael, Schneck Kaitlyn, Reske Melissa, Knowles Michael R, Pier Gerald B, Lange Christoph, Weiss Scott T
Abstract excerpt
RATIONALE: Variability in pulmonary disease severity is found in patients with cystic fibrosis (CF) who have identical mutations in the CF transmembrane conductance regulator (CFTR) gene. We hypothesized that one factor accounting for heterogeneity in pulmonary disease severity is variation in the family of genes affecting the biology of interleukin-1 (IL-1), which impacts acquisition and maintenance of...
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