Article
Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis.
American journal of respiratory cell and molecular biology - 1 Nov 2015
Saferali Aabida, Obeidat Ma'en, Bérubé Jean-Christophe, Lamontagne Maxime, Bossé Yohan, Laviolette Michel, Hao Ke, Nickle David C, Timens Wim, Sin Don D, Postma Dirkje S, Strug Lisa J, Gallins Paul J, Paré Peter D, Bingle Colin D, Sandford Andrew J
Abstract excerpt
BPI fold containing family A, member 1 (BPIFA1) and BPIFB1 are putative innate immune molecules expressed in the upper airways. Because of their hypothesized roles in airway defense, these molecules may contribute to lung disease severity in cystic fibrosis (CF). We interrogated BPIFA1/BPIFB1 single-nucleotide polymorphisms in data from an association study of CF modifier genes and found an association of the G...
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