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Cytokine gene polymorphisms and severity of CF lung disease.

Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Dec 2014

de Vries Leonieke, Griffiths Amanda, Armstrong David, Robinson Philip J

Abstract excerpt

BACKGROUND: The search for modifier genes to explain inconsistencies in cystic fibrosis (CF) genotype-phenotype relationships has yielded mixed results. In a previous cross-sectional study from our centre the clinical effect (as described by FEV1, BMI z-score, admitted days and NIH score) of single nucleotide polymorphisms (SNPs) of four cytokine genes (IL-8, TNF-α, IL-1β and IL-10) was examined in 158 children...

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PMID: 24853301
DOI: 10.1016/j.jcf.2014.04.007

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TNF

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