Article
Interaction between a novel TGFB1 haplotype and CFTR genotype is associated with improved lung function in cystic fibrosis.
Human molecular genetics - 15 Jul 2008
Bremer Lindsay A, Blackman Scott M, Vanscoy Lori L, McDougal Kathryn E, Bowers Amanda, Naughton Kathleen M, Cutler David J, Cutting Garry R
Abstract excerpt
Cystic fibrosis (CF), the most common lethal single gene disorder in Caucasians, is due to mutations in the CFTR gene. Twin and sibling analysis indicates that modifier genes, rather than allelic variation in CFTR, are responsible for most of the variability in severity of lung disease, the major cause of mortality in CF patients. We used a family-based approach to test for association between lung function and...
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