Gene modifiers of lung disease.

Abstract excerpt

PURPOSE OF REVIEW: Cystic fibrosis is a recessive genetic disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, but there is great heterogeneity of lung-disease severity. If we could understand non-CFTR genetic factors (modifier genes) that contribute to the severity of lung disease, we could develop novel therapies. Early studies were small and/or phenotyping...

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