Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1.

PloS one - 1 Jan 2020

Saferali Aabida, Tang Anthony C, Strug Lisa J, Quon Bradley S, Zlosnik James, Sandford Andrew J, Turvey Stuart E

Abstract excerpt

BACKGROUND: Cystic fibrosis (CF) is characterized by a progressive decline in lung function due to airway obstruction, infection, and inflammation. CF patients are particularly susceptible to respiratory infection by a variety of pathogens, and the inflammatory response in CF is dysregulated and prolonged. BPI fold containing family A, member 1 (BPIFA1) and BPIFB1 are proteins expressed in the upper airways that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autoantigens
Share to Cystic Fibrosis
Share to Fatty Acid-Binding Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, Modifier

Share to Glycoproteins

Share to Phosphoproteins

Share to Pneumonia

Share to Respiratory Mucosa

Source

Open in PubMed Open full text

Identifiers

PMID: 31931521
DOI: 10.1371/journal.pone.0227067
PMCID: PMC6957340

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunomodulatory function of the cystic fibrosis modifier gene BPIFA1.PMID 31931521Read ↗

Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis.Semantic proximity Read ↗

Update on gene modifiers in cystic fibrosisSemantic proximity Read ↗

Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.Semantic proximity Read ↗

Modifier genes in cystic fibrosis lung disease.Semantic proximity Read ↗

IFRD1 modulates disease severity in cystic fibrosis through the regulation of neutrophil effector functionSemantic proximity Read ↗

BPIFB1 (LPLUNC1) is upregulated in cystic fibrosis lung diseaseSemantic proximity Read ↗

Genome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosisSemantic proximity Read ↗

Transcriptomic profile of cystic fibrosis patients identifies type I interferon response and ribosomal stalk proteins as potential modifiers of disease severity.Semantic proximity Read ↗

Modifier gene studies to identify new therapeutic targets in cystic fibrosis.Semantic proximity Read ↗

TLR5 as an anti-inflammatory target and modifier gene in cystic fibrosis.Semantic proximity Read ↗

Expression and regulation of interferon-related development regulator-1 in cystic fibrosis neutrophils.Semantic proximity Read ↗

Phenotype of CF and the effects of possible modifier genes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.