Article
Airway Mucosal Host Defense Is Key to Genomic Regulation of Cystic Fibrosis Lung Disease Severity.
American journal of respiratory and critical care medicine - 1 Jan 2018
Polineni Deepika, Dang Hong, Gallins Paul J, Jones Lisa C, Pace Rhonda G, Stonebraker Jaclyn R, Commander Leah A, Krenicky Jeanne E, Zhou Yi-Hui, Corvol Harriet, Cutting Garry R, Drumm Mitchell L, Strug Lisa J, Boyle Michael P, Durie Peter R, Chmiel James F, Zou Fei, Wright Fred A, O'Neal Wanda K, Knowles Michael R
Abstract excerpt
RATIONALE: The severity of cystic fibrosis (CF) lung disease varies widely, even for Phe508del homozygotes. Heritability studies show that more than 50% of the variability reflects non-cystic fibrosis transmembrane conductance regulator (CFTR) genetic variation; however, the full extent of the pertinent genetic variation is not known. OBJECTIVES: We sought to identify novel CF disease-modifying mechanisms using...
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