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Article

Genetic variations in inflammatory mediators influence lung disease progression in cystic fibrosis.

Pediatric pulmonology - 1 Dec 2008

Corvol Harriet, Boelle Pierre-Yves, Brouard Jacques, Knauer Nicola, Chadelat Katarina, Henrion-Caude Alexandra, Flamant Cyril, Muselet-Charlier Celine, Boule Michele, Fauroux Brigitte, Vallet Christelle, Feingold Josue, Ratjen Felix, Grasemann Hartmut, Clement Annick

Abstract excerpt

The clinical course of cystic fibrosis (CF) varies considerably among patients carrying the same CF-causing gene mutation. Additional genetic modifiers may contribute to this variability. As airway inflammation is a key component of CF pathophysiology, we investigated whether major cytokine variants represent such modifiers in young CF patients. We tested 13 polymorphisms in 8 genes that play a key role in the...

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PMID: 19009622
DOI: 10.1002/ppul.20935

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TGFB1
FEV

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