Article
Genetic modifiers of lung disease in cystic fibrosis.
The New England journal of medicine - 6 Oct 2005
Drumm Mitchell L, Konstan Michael W, Schluchter Mark D, Handler Allison, Pace Rhonda, Zou Fei, Zariwala Maimoona, Fargo David, Xu Airong, Dunn John M, Darrah Rebecca J, Dorfman Ruslan, Sandford Andrew J, Corey Mary, Zielenski Julian, Durie Peter, Goddard Katrina, Yankaskas James R, Wright Fred A, Knowles Michael R
Abstract excerpt
BACKGROUND: Polymorphisms in genes other than the cystic fibrosis transmembrane conductance regulator (CFTR) gene may modify the severity of pulmonary disease in patients with cystic fibrosis. METHODS: We performed two studies with different patient samples. We first tested 808 patients who were homozygous for the DeltaF508 mutation and were classified as having either severe or mild lung disease, as defined by...
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