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Article

Further genetic evidence suggesting a role for the RhoGTPase-RhoGEF pathway in osteoporosis.

Bone - 1 Aug 2009

Mullin Ben H, Prince Richard L, Mamotte Cyril, Spector Tim D, Hart Deborah J, Dudbridge Frank, Wilson Scott G

Abstract excerpt

Osteoporosis is a highly heritable trait that appears to be influenced by multiple genes. Genome-wide linkage studies have highlighted the chromosomal region 3p14-p21 as a quantitative trait locus for BMD. We have previously published evidence suggesting that the ARHGEF3 gene from this region is associated with BMD in women. The product of this gene activates the RHOA GTPase, the gene for which is also located...

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Source

Identifiers

PMID: 19427924
DOI: 10.1016/j.bone.2009.04.254

Genes

RHOA
ARHGEF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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