Article
Multiple genetic loci for bone mineral density and fractures.
The New England journal of medicine - 29 May 2008
Styrkarsdottir Unnur, Halldorsson Bjarni V, Gretarsdottir Solveig, Gudbjartsson Daniel F, Walters G Bragi, Ingvarsson Thorvaldur, Jonsdottir Thorbjorg, Saemundsdottir Jona, Center Jacqueline R, Nguyen Tuan V, Bagger Yu, Gulcher Jeffrey R, Eisman John A, Christiansen Claus, Sigurdsson Gunnar, Kong Augustine, Thorsteinsdottir Unnur, Stefansson Kari
Abstract excerpt
BACKGROUND: Bone mineral density influences the risk of osteoporosis later in life and is useful in the evaluation of the risk of fracture. We aimed to identify sequence variants associated with bone mineral density and fracture. METHODS: We performed a quantitative trait analysis of data from 5861 Icelandic subjects (the discovery set), testing for an association between 301,019 single-nucleotide polymorphisms...
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