Article
Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.
Lancet (London, England) - 3 May 2008
Richards J B, Rivadeneira F, Inouye M, Pastinen T M, Soranzo N, Wilson S G, Andrew T, Falchi M, Gwilliam R, Ahmadi K R, Valdes A M, Arp P, Whittaker P, Verlaan D J, Jhamai M, Kumanduri V, Moorhouse M, van Meurs J B, Hofman A, Pols H A P, Hart D, Zhai G, Kato B S, Mullin B H, Zhang F, Deloukas P, Uitterlinden A G, Spector T D
Abstract excerpt
BACKGROUND: Osteoporosis is diagnosed by the measurement of bone mineral density, which is a highly heritable and multifactorial trait. We aimed to identify genetic loci that are associated with bone mineral density. METHODS: In this genome-wide association study, we identified the most promising of 314 075 single nucleotide polymorphisms (SNPs) in 2094 women in a UK study. We then tested these SNPs for...
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