Article
Polymorphisms in genes involved in the NF-κB signalling pathway are associated with bone mineral density, geometry and turnover in men.
PloS one - 1 Jan 2011
Roshandel Delnaz, Thomson Wendy, Pye Stephen R, Boonen Steven, Borghs Herman, Vanderschueren Dirk, Huhtaniemi Ilpo T, Adams Judith E, Ward Kate A, Bartfai Gyorgy, Casanueva Felipe F, Finn Joseph D, Forti Gianni, Giwercman Aleksander, Han Thang S, Kula Krzysztof, Lean Michael E, Pendleton Neil, Punab Margus, Wu Frederick C, Holliday Kate L, O'Neill Terence W
Abstract excerpt
INTRODUCTION: In this study, we aimed to investigate the association between single nucleotide polymorphisms (SNPs) within two genes involved in the NF-κB cascade (GPR177 and MAP3K14) and bone mineral density (BMD) assessed at different skeletal sites, radial geometric parameters and bone turnover. METHODS: Ten GPR177 SNPs previously associated with BMD with genome-wide significance and twelve tag SNPs (r(2)≥0.8)...
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