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Article

Identification of a role for the ARHGEF3 gene in postmenopausal osteoporosis.

American journal of human genetics - 1 Jun 2008

Mullin Ben H, Prince Richard L, Dick Ian M, Hart Deborah J, Spector Tim D, Dudbridge Frank, Wilson Scott G

Abstract excerpt

Osteoporosis is a common and debilitating bone disease characterized by low bone mineral density (BMD), a highly heritable and polygenic trait. Genome-wide linkage studies have identified 3p14-p21 as a quantitative trait locus for BMD. The ARHGEF3 gene is situated within this region and was identified as a strong positional candidate. The aim of this study was to evaluate the role of variation in ARHGEF3 on bone...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18499081
DOI: 10.1016/j.ajhg.2008.04.016
PMCID: PMC2427258

Genes

ARHGEF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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