Article
Robust and comprehensive analysis of 20 osteoporosis candidate genes by very high-density single-nucleotide polymorphism screen among 405 white nuclear families identified significant association and gene-gene interaction.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2006
Xiong Dong-Hai, Shen Hui, Zhao Lan-Juan, Xiao Peng, Yang Tie-Lin, Guo Yan, Wang Wei, Guo Yan-Fang, Liu Yong-Jun, Recker Robert R, Deng Hong-Wen
Abstract excerpt
UNLABELLED: Many "novel" osteoporosis candidate genes have been proposed in recent years. To advance our knowledge of their roles in osteoporosis, we screened 20 such genes using a set of high-density SNPs in a large family-based study. Our efforts led to the prioritization of those osteoporosis genes and the detection of gene-gene interactions. INTRODUCTION: We performed large-scale family-based association...
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