Article
Defining multiple common "completely" conserved major histocompatibility complex SNP haplotypes.
Clinical immunology (Orlando, Fla.) - 1 Aug 2009
Baschal Erin E, Aly Theresa A, Jasinski Jean M, Steck Andrea K, Noble Janelle A, Erlich Henry A, Eisenbarth George S
Abstract excerpt
The availability of both HLA data and genotypes for thousands of SNPs across the major histocompatibility complex (MHC) in 1240 complete families of the Type 1 Diabetes Genetics Consortium allowed us to analyze the occurrence and extent of megabase contiguous identity for founder chromosomes from unrelated individuals. We identified 82 HLA-defined haplotype groups, and within these groups, megabase regions of SNP...
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