Article
Multi-SNP analysis of MHC region: remarkable conservation of HLA-A1-B8-DR3 haplotype.
Diabetes - 1 May 2006
Aly Theresa A, Eller Elise, Ide Akane, Gowan Katherine, Babu Sunanda R, Erlich Henry A, Rewers Marian J, Eisenbarth George S, Fain Pamela R
Abstract excerpt
Technology has become available to cost-effectively analyze thousands of single nucleotide polymorphisms (SNPs). We recently confirmed by genotyping a small series of class I alleles and microsatellite markers that the extended haplotype HLA-A1-B8-DR3 (8.1 AH) at the major histocompatibility complex (MHC) is a common and conserved haplotype. To further evaluate the region of conservation of the DR3 haplotypes, we...
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