Article
The frequent and conserved DR3-B8-A1 extended haplotype confers less diabetes risk than other DR3 haplotypes.
Diabetes, obesity & metabolism - 1 Feb 2009
Baschal E E, Aly T A, Jasinski J M, Steck A K, Johnson K N, Noble J A, Erlich H A, Eisenbarth G S
Abstract excerpt
AIM: The goal of this study was to develop and implement methodology that would aid in the analysis of extended high-density single nucleotide polymorphism (SNP) major histocompatibility complex (MHC) haplotypes combined with human leucocyte antigen (HLA) alleles in relation to type 1 diabetes risk. METHODS: High-density SNP genotype data (2918 SNPs) across the MHC from the Type 1 Diabetes Genetics Consortium...
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