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Analysis of single nucleotide polymorphisms identifies major type 1A diabetes locus telomeric of the major histocompatibility complex.

Diabetes - 1 Mar 2008

Aly Theresa A, Baschal Erin E, Jahromi Mohamed M, Fernando Maria S, Babu Sunanda R, Fingerlin Tasha E, Kretowski Adam, Erlich Henry A, Fain Pamela R, Rewers Marian J, Eisenbarth George S

Abstract excerpt

OBJECTIVE: HLA-DRB1*03-DQB1*0201/DRB1*04-DQB1*0302 (DR3/4-DQ8) siblings who share both major histocompatibility complex (MHC) haplotypes identical-by-descent with their proband siblings have a higher risk for type 1A diabetes than DR3/4-DQ8 siblings who do not share both MHC haplotypes identical-by-descent. Our goal was to search for non-DR/DQ MHC genetic determinants that cause the additional risk in the...

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PMID: 18065518
DOI: 10.2337/db07-0900

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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