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Expanded Allelic Diversity of Non-Classical HLA Class I and MIC Loci Identified Using Full-Gene Hybrid Capture-Based Next-Generation Sequencing.

HLA - 1 Jul 2026

Chaaithanya Itta Krishna, Raghav Pawan Kumar, Lee Nancy, Wirtz Carla, Kong Denice, Rajalingam Raja

Abstract excerpt

Non-classical HLA Class I genes (HLA-E, -F, -G, -H) and MHC-related genes (MICA, MICB) regulate NK cell function and immune tolerance, yet their allelic diversity remains underexplored. Using capture-enriched full-gene sequencing of 943 healthy US transplant donors, we identified 26 novel alleles across HLA-E (2), HLA-F (6), HLA-G (4), HLA-H (5), MICA (3), and MICB (6). Each novel allele was identified in a...

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Identifiers

PMID: 42366455
DOI: 10.1111/tan.70824
PMCID: PMC13310964

Genes

MICA
MICB

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 16 Oct 2026.

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