Article
Generation of mtDNA-exchanged cybrids for determination of the effects of mtDNA mutations on tumor phenotypes.
Methods in enzymology - 1 Jan 2009
Ishikawa Kaori, Hayashi Jun-Ichi
Abstract excerpt
It has been proposed that mutations of mitochondrial DNA (mtDNA) and resultant mitochondrial dysfunction induce various phenotypes, such as mitochondrial diseases, aging, and tumorigenesis. However, it is difficult to conclude whether mtDNA mutations are truly responsible for these phenotypes due to the regulation of the mitochondrial functions by both mtDNA and nuclear DNA. The mtDNA-exchange techniques are very...
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