Article
The N-terminal domain of GluD2 (GluRdelta2) recruits presynaptic terminals and regulates synaptogenesis in the cerebellum in vivo.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 May 2009
Kakegawa Wataru, Miyazaki Taisuke, Kohda Kazuhisa, Matsuda Keiko, Emi Kyoichi, Motohashi Junko, Watanabe Masahiko, Yuzaki Michisuke
Abstract excerpt
The delta2 glutamate receptor (GluRdelta2; GluD2), which is predominantly expressed on postsynaptic sites at parallel fiber (PF)-Purkinje cell synapses in the cerebellum, plays two crucial roles in the cerebellum: the formation of PF synapses and the regulation of long-term depression (LTD), a form of synaptic plasticity underlying motor learning. Although the induction of LTD and motor learning absolutely...
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