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Article

D-serine regulates cerebellar LTD and motor coordination through the δ2 glutamate receptor.

Nature neuroscience - 1 May 2011

Kakegawa Wataru, Miyoshi Yurika, Hamase Kenji, Matsuda Shinji, Matsuda Keiko, Kohda Kazuhisa, Emi Kyoichi, Motohashi Junko, Konno Ryuichi, Zaitsu Kiyoshi, Yuzaki Michisuke

Abstract excerpt

D-serine (D-Ser) is an endogenous co-agonist for NMDA receptors and regulates neurotransmission and synaptic plasticity in the forebrain. D-Ser is also found in the cerebellum during the early postnatal period. Although D-Ser binds to the δ2 glutamate receptor (GluD2, Grid2) in vitro, its physiological significance has remained unclear. Here we show that D-Ser serves as an endogenous ligand for GluD2 to regulate...

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PMID: 21460832
DOI: 10.1038/nn.2791

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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