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Article

Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression.

Neuron - 16 Mar 2006

Steinberg Jordan P, Takamiya Kogo, Shen Ying, Xia Jun, Rubio Maria E, Yu Sandy, Jin Wenying, Thomas Gareth M, Linden David J, Huganir Richard L

Abstract excerpt

Cerebellar long-term depression (LTD) is a major form of synaptic plasticity that is thought to be critical for certain types of motor learning. Phosphorylation of the AMPA receptor subunit GluR2 on serine-880 as well as interaction of GluR2 with PICK1 have been suggested to contribute to the endocytic removal of postsynaptic AMPA receptors during LTD. Here, we show that targeted mutation of PICK1, the GluR2...

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Source

Identifiers

PMID: 16543133
DOI: 10.1016/j.neuron.2006.02.025

Genes

PICK1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Targeted in vivo mutations of the AMPA receptor subunit GluR2 and its interacting protein PICK1 eliminate cerebellar long-term depression.PMID 16543133Read ↗

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