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Article

The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 28 May 2008

Takamiya Kogo, Mao Lifang, Huganir Richard L, Linden David J

Abstract excerpt

Glutamate receptor-interacting protein 1 (GRIP1) and GRIP2 are closely related proteins that bind GluR2-containing AMPA receptors and couple them to structural and signaling complexes in neurons. Cerebellar long-term synaptic depression (LTD) is a model system of synaptic plasticity that is expressed by persistent internalization of GluR2-containing AMPA receptors. Here, we show that genetic deletion of both...

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Identifiers

PMID: 18509036
DOI: 10.1523/JNEUROSCI.0654-08.2008
PMCID: PMC2587083

Genes

GRIP1
GRIP2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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