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Article

Ca2+ permeability of the channel pore is not essential for the delta2 glutamate receptor to regulate synaptic plasticity and motor coordination.

The Journal of physiology - 15 Mar 2007

Kakegawa Wataru, Miyazaki Taisuke, Hirai Hirokazu, Motohashi Junko, Mishina Masayoshi, Watanabe Masahiko, Yuzaki Michisuke

Abstract excerpt

The delta2 glutamate receptor (GluRdelta2) plays a crucial role in cerebellar functions; mice with a disrupted GluRdelta2 gene (GluRdelta2-/-) display impaired synapse formation and abrogated long-term depression (LTD). However, the mechanisms by which GluRdelta2 functions have remained unclear. Because a GluRdelta2 mutation in lurcher mice causes channel activities characterized by Ca2+ permeability, GluRdelta2...

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Identifiers

PMID: 17255161
DOI: 10.1113/jphysiol.2006.127100
PMCID: PMC2151382

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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