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Article

AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.

American journal of physiology. Cell physiology - 1 Jul 2009

King J Darwin, Fitch Adam C, Lee Jeffrey K, McCane Jill E, Mak Don-On Daniel, Foskett J Kevin, Hallows Kenneth R

Abstract excerpt

The metabolic sensor AMP-activated protein kinase (AMPK) has emerged as an important link between cellular metabolic status and ion transport activity. We previously found that AMPK binds to and phosphorylates CFTR in vitro and inhibits PKA-dependent stimulation of CFTR channel gating in Calu-3 bronchial serous gland epithelial cells. To further characterize the mechanism of AMPK-dependent regulation of CFTR,...

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Identifiers

PMID: 19419994
DOI: 10.1152/ajpcell.00677.2008
PMCID: PMC2711654

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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