Article
AMP-activated protein kinase regulates hERG potassium channel.
Pflugers Archiv : European journal of physiology - 1 Nov 2013
Almilaji Ahmad, Munoz Carlos, Elvira Bernat, Fajol Abul, Pakladok Tatsiana, Honisch Sabina, Shumilina Ekaterina, Lang Florian, Föller Michael
Abstract excerpt
Besides their role in cardiac repolarization, human ether-a-go-go-related gene potassium (hERG) channels are expressed in several tumor cells including rhabdomyosarcoma cells. The channels foster cell proliferation. Ubiquitously expressed AMP-dependent protein kinase (AMPK) is a serine-/threonine kinase, stimulating energy-generating and inhibiting energy-consuming processes thereby helping cells survive periods...
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