Article
Phosphorylation of protein kinase C sites in NBD1 and the R domain control CFTR channel activation by PKA.
The Journal of physiology - 1 Apr 2003
Chappe V, Hinkson D A, Zhu T, Chang X-B, Riordan J R, Hanrahan J W
Abstract excerpt
Activation of the cystic fibrosis transmembrane conductance regulator (CFTR) channel by protein kinase A (PKA) is enhanced by protein kinase C (PKC). However, the mechanism of modulation is not known and it remains uncertain whether PKC acts directly on CFTR or through phosphorylation of an ancillary protein. Using excised patches that had been pre-treated with phosphatases, we found that PKC exposure results in...
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