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Article

Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase.

The Journal of biological chemistry - 28 Sept 2012

King J Darwin, Lee Jeffrey, Riemen Claudia E, Neumann Dietbert, Xiong Sheng, Foskett J Kevin, Mehta Anil, Muimo Richmond, Hallows Kenneth R

Abstract excerpt

Cystic fibrosis transmembrane conductance regulator (CFTR) Cl(-) channel mutations cause cystic fibrosis lung disease. A better understanding of CFTR regulatory mechanisms could suggest new therapeutic strategies. AMP-activated protein kinase (AMPK) binds to and phosphorylates CFTR, attenuating P...

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Identifiers

PMID: 22869372
DOI: 10.1074/jbc.M112.396036
PMCID: PMC3460441

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22869372-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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Role of binding and nucleoside diphosphate kinase A in the regulation of the cystic fibrosis transmembrane conductance regulator by AMP-activated protein kinase.PMID 22869372Read ↗

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