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Article

Downregulation of the renal outer medullary K(+) channel ROMK by the AMP-activated protein kinase.

Pflugers Archiv : European journal of physiology - 1 Feb 2013

Siraskar Balasaheb, Huang Dan Yang, Pakladok Tatsiana, Siraskar Gulab, Sopjani Mentor, Alesutan Ioana, Kucherenko Yulia, Almilaji Ahmad, Devanathan Vasudharani, Shumilina Ekaterina, Föller Michael, Munoz Carlos, Lang Florian

Abstract excerpt

The 5'-adenosine monophosphate-activated serine/threonine protein kinase (AMPK) is stimulated by energy depletion, increase in cytosolic Ca(2+) activity, oxidative stress, and nitric oxide. AMPK participates in the regulation of the epithelial Na(+) channel ENaC and the voltage-gated K(+) channel KCNE1/KCNQ1. It is partially effective by decreasing PIP(2) formation through the PI3K pathway. The present study...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23179379
DOI: 10.1007/s00424-012-1180-1

Genes

KCNQ1
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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