Article

Structural determinants of protein kinase A essential for CFTR channel activation

2024-06-01

Abstract excerpt

CFTR, the anion channel mutated in cystic fibrosis (CF) patients, is activated by the catalytic subunit of protein kinase A (PKA-C). PKA-C activates CFTR both reversibly, through binding, and irreversibly, through phosphorylation of multiple serines in CFTR’s regulatory (R) domain. Here we identify key molecular determinants of the CFTR/PKA-C interaction essential for these processes. By comparing CFTR current act...

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Literature Corpus work: 914ee345-46b0-56b5-b913-675ab974a9be
DOI: 10.1101/2024.05.27.596024

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